TNFSF8 monoclonal antibody (M03), clone 3G9
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More Files
- More Functions
Western Blot detection against Immunogen (21.12 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant TNFSF8.
Immunogen
TNFSF8 (AAH93630.1, 63 a.a. ~ 234 a.a) partial recombinant protein.
Sequence
QRTDSIPNSPDNVPLKGGNCSEDLLCILKRAPFKKSWAYLQVAKHLNKTKLSWNKDGILHGVRYQDGNLVIQFPGLYFIICQLQFLVQCPNNSVDLKLELLINKHIKKQALVTVCESGMQTKHVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTSTFPLENVLSIFLYSNSD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (75)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (21.12 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — TNFSF8
Entrez GeneID
944GeneBank Accession#
BC093630.1Protein Accession#
AAH93630.1Gene Name
TNFSF8
Gene Alias
CD153, CD30L, CD30LG, MGC138144
Gene Description
tumor necrosis factor (ligand) superfamily, member 8
Omim ID
603875Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. [provided by RefSeq
Other Designations
CD153 antigen|CD30 antigen ligand|CD30 ligand|OTTHUMP00000022762
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Interactome
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Pathway
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Disease
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