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Last updated: 2014/4/21
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BIOtech
BULK-new

APH1A polyclonal antibody

  • Catalog # : PAB7304
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of APH1A.
  • Immunogen:
  • A synthetic peptide corresponding to human APH1A.
  • Sequence:
  • C-HVTDRSDARLQYG
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 28.9, 26.8
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to recognize both reported isoforms (NP_001071096.1 and NP_057106.2).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:128000)
    Western Blot (0.05-0.1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • APH1A polyclonal antibody (Cat # PAB7304) (0.05 ug/mL) staining of human brain (cerebral cortex) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Protein Accession#:
  • NP_001071096.1;NP_057106.2
  • Gene Name:
  • APH1A
  • Gene Alias:
  • 6530402N02Rik,APH-1A,CGI-78
  • Gene Description:
  • anterior pharynx defective 1 homolog A (C. elegans)
  • Gene Summary:
  • APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM
  • Other Designations:
  • OTTHUMP00000014528,OTTHUMP00000014529,anterior pharynx defective 1 homolog A
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