Products

Western Blot (Cell lysate)

Western blot analysis of AARS polyclonal antibody (Cat # PAB2957) in K-562 cell line lysates (35 ug/lane).AARS (arrow) was detected using the purified polyclonal antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with AARS polyclonal antibody (Cat # PAB2957) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Entrez GeneID

16

Protein Accession#

NP_001596;P49588

Gene Name

AARS

Gene Alias

-

Gene Description

alanyl-tRNA synthetase

Omim ID

601065

Gene Ontology

Hyperlink

Gene Summary

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq

Other Designations

alanine tRNA ligase 1, cytoplasmic