ERBB2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ERBB2.
Immunogen
A synthetic peptide corresponding to human ERBB2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ERBB2.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence analysis of HeLa cells, using ERBB2 polyclonal antibody (Cat # PAB18364).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ERBB2
Entrez GeneID
2064Protein Accession#
P04626Gene Name
ERBB2
Gene Alias
CD340, HER-2, HER-2/neu, HER2, NEU, NGL, TKR1
Gene Description
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq
Other Designations
c-erb B2/neu protein|erbB-2|herstatin|neuroblastoma/glioblastoma derived oncogene homolog|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
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Interactome
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Pathway
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Disease
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Publication Reference
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Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.
Swiercz JM, Kuner R, Offermanns S.
The Journal of Cell Biology 2004 Jun; 165(6):869.
Application:IF, WB-Tr, Human, HEK 293 cells, Hippocampal neurons.
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Memo mediates ErbB2-driven cell motility.
Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A.
Nature Cell Biology 2004 Jun; 6(6):515.
Application:WB, Human, SKBr3 cells.
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Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.
Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J.
Molecular and Cellular Biology 2000 Jun; 20(11):3817.
Application:IP, Human, A431 cells.
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Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.
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