BIRC7 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BIRC7 expression in human Raji cell lysate with BIRC7 polyclonal antibody (Cat # PAB12872) at 4 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BIRC7 in human small intestine tissue with BIRC7 polyclonal antibody (Cat # PAB12872) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIRC7.
Immunogen
A mixture of synthetic peptides corresponding to amino acids 264-280 of the short form and 281-298 of the long form of human BIRC7.
Host
Rabbit
Reactivity
Human
Specificity
This sequence is identical between a and b forms of the Livin proteins.
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BIRC7 expression in human Raji cell lysate with BIRC7 polyclonal antibody (Cat # PAB12872) at 4 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BIRC7 in human small intestine tissue with BIRC7 polyclonal antibody (Cat # PAB12872) at 5 ug/mL . -
Gene Info — BIRC7
Entrez GeneID
79444Protein Accession#
NP_071444Gene Name
BIRC7
Gene Alias
KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Gene Description
baculoviral IAP repeat-containing 7
Omim ID
605737Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq
Other Designations
OTTHUMP00000031536|OTTHUMP00000031537|baculoviral IAP repeat-containing protein 7|kidney inhibitor of apoptosis protein|livin inhibitor of apoptosis|livin inhibitor-of-apoptosis|melanoma inhibitor of apoptosis protein
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Interactome
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Publication Reference
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Expression of Livin and PlGF in human osteosarcoma is associated with tumor progression and clinical outcome.
Sun K, Liao Q, Chen Z, Chen T, Zhang J.
Oncology Letters 2018 Oct; 16(4):4953.
Application：IHC-P, Human, Human osteosarcoma.
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Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern.
Ashhab Y, Alian A, Polliack A, Panet A, Ben Yehuda D.
FEBS Lett 2001 Apr; 495(1-2):56.
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KIAP, a novel member of the inhibitor of apoptosis protein family.
Lin JH, Deng G, Huang Q, Morser J.
Biochemical and Biophysical Research Communications 2000 Dec; 279(3):820.
Application：WB-Tr, Human, 293 cells.
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Livin, a novel inhibitor of apoptosis protein family member.
Kasof GM, Gomes BC.
The Journal of Biological Chemistry 2001 Feb; 276(5):3238.
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Expression of Livin and PlGF in human osteosarcoma is associated with tumor progression and clinical outcome.
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