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BIOtech
BULK-new

HLA-DQA1 monoclonal antibody, clone TAL 4.1

  • Catalog # : MAB7017
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native HLA-DQA1.
  • Immunogen:
  • Native purified HLA-DQA1 from whole cells from the B line WT46.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • HLA DQ (TAL 4.1). Predicted molecular weight 28 KDa.
  • Form:
  • Liquid
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS
  • Storage Instruction:
  • Store at 4°C for short term. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry
  • ELISA
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • ELISA
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3117
  • Gene Name:
  • HLA-DQA1
  • Gene Alias:
  • CD,CELIAC1,DQ-A1,FLJ27088,FLJ27328,GSE,HLA-DQA,MGC149527
  • Gene Description:
  • major histocompatibility complex, class II, DQ alpha 1
  • Gene Summary:
  • HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq
  • Other Designations:
  • Gluten-sensitive enteropathy (celiac disease),MHC HLA-DQ alpha,MHC class II HLA-D alpha glycoprotein,MHC class II HLA-DQ-alpha-1,MHC class II antigen,MHC class II surface glycoprotein,OTTHUMP00000029141,OTTHUMP00000176885,OTTHUMP00000178551,OTTHUMP0000017
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