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Last updated: 2015/5/3
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ARAP1 monoclonal antibody, clone ARAP1-2

  • Catalog # : MAB3599
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant ARAP1.
  • Immunogen:
  • Recombinant His6 fusion protein corresponding to amino acids 1190-1450 of human ARAP1.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 160
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with C-terminal part of ARAP1, a 160 KDa adaptor protein.
  • Form:
  • Liquid
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (2 ug/m)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (15 mM sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunocytochemistry
  • Immunofluorescence
  • Immunofluorescence
  • Colocalization of ARAP1 with DR4 at the human plasma membrane and in early endosomes. ARAP1-transfected NCTC cells were treated with TRAIL for 0', 30' or 60' and fixed with methanol. DR4 was detected by rabbit polyclonal (red) and ARAP1 with ARAP1 monoclonal antibody, clone ARAP1-2 (green). Arrowheads show ARAP1-DR4 colocalization at the plasma membrane and intracellular membranes, whereas arrows show their colocalization in early endosomes.
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunocytochemistry
  • Immunoprecipitation
  • Gene Information
  • Gene Name:
  • ARAP1
  • Gene Alias:
  • CENTD2,KIAA0782
  • Gene Description:
  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • Gene Summary:
  • The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1,centaurin, delta 2
  • Gene Pathway
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