TP53 (phospho S46) monoclonal antibody, clone 36
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Specifications
Product Description
Mouse monoclonal antibody raised against synthetic phosphopeptide of TP53.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S46 of human TP53.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Identification of TP53 (phospho-S46) monoclonal antibody, clone 36 (Cat # MAB0659) by Western blotting. Using crude cell extracts of MOLT 4 untreated (left lanes) and treated with adriamycin for 24 h (right lanes). The left panel is the result with our product and right panel is the one obtained withthe product of our competitor. The lower panel is whole TP53 protein identified by omnipotent anti-TP53 antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of TP53 (phospho-S46) monoclonal antibody, clone 36 (Cat # MAB0659) on formalin-fixed paraffin-embedded human stomach.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of TP53 (phospho-S46) monoclonal antibody, clone 36 (Cat # MAB0659) on formalin-fixed paraffin-embedded human colon.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of TP53 (phospho-S46) monoclonal antibody, clone 36 (Cat # MAB0659) on formalin-fixed paraffin-embedded human ovary.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TP53
Entrez GeneID
7157Gene Name
TP53
Gene Alias
FLJ92943, LFS1, TRP53, p53
Gene Description
tumor protein p53
Gene Ontology
HyperlinkGene Summary
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
Other Designations
p53 antigen|p53 transformation suppressor|p53 tumor suppressor|phosphoprotein p53|transformation-related protein 53
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Interactomes
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