B2M (Human) ELISA Kit
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Specifications
Product Description
B2M (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human B2M.
Suitable Sample
Cell Culture Samples, CSF, Milk, Plasma, Saliva, Serum, Urine
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
0.049 to 50 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — B2M
Entrez GeneID
567Gene Name
B2M
Gene Alias
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Gene Description
beta-2-microglobulin
Gene Ontology
HyperlinkGene Summary
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia
Other Designations
beta chain of MHC class I molecules|beta-2-microglobin
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma.
Zhang L, Yao Y, Zhang S, Liu Y, Guo H, Ahmed M, Bell T, Zhang H, Han G, Lorence E, Badillo M, Zhou S, Sun Y, Di Francesco ME, Feng N, Haun R, Lan R, Mackintosh SG, Mao X, Song X, Zhang J, Pham LV, Lorenzi PL, Marszalek J, Heffernan T, Draetta G, Jones P, Futreal A, Nomie K, Wang L, Wang M.
Science Translational Medicine 2019 May; 11(491):eaau1167.
Application:Quant, Mouse, Mouse serum.
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A native to amyloidogenic transition regulated by a backbone trigger.
Eakin CM, Berman AJ, Miranker AD.
Nature Structural & Molecular Biology 2006 Mar; 13(3):202.
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Quantification of cleaved beta2-microglobulin in serum from patients undergoing chronic hemodialysis.
Corlin DB, Sen JW, Ladefoged S, Lund GB, Nissen MH, Heegaard NH.
Clinical Chemistry 2005 Jul; 51(7):1177.
Application:Quant, Human, Human serum.
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Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties.
Trinh CH, Smith DP, Kalverda AP, Phillips SE, Radford SE.
PNAS 2002 Jul; 99(15):9771.
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Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma.
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