IL18 (Human) ELISA Kit
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Specifications
Product Description
IL18 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human IL18.
Suitable Sample
Cell Culture Supernatant, Cell Lysates, Plasma (EDTA, Heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
31.2 to 2000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — IL18
Entrez GeneID
3606Gene Name
IL18
Gene Alias
IGIF, IL-18, IL-1g, IL1F4, MGC12320
Gene Description
interleukin 18 (interferon-gamma-inducing factor)
Omim ID
600953Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq
Other Designations
IL-1 gamma|interferon-gamma-inducing factor|interleukin 18|interleukin-1 gamma|interleukin-18
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Diagnostic Evaluation Using Salivary Gland Ultrasonography in Primary Sjögren's Syndrome.
Yen-Fu Chen, Ao-Ho Hsieh, Yao-Fan Fang, Chang-Fu Kuo.
Journal of Clinical Medicine 2023 Mar; 12(6):2428.
Application:Quant, Human, Human serum.
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IFN-γ and IL-18 in conditioned media of parasite-infected host and IL-21-silenced colorectal cancer cells.
Peng Ge, Ching Yi Ong, Abdalla Eshtiyag Abdalkareem, Boon Yin Khoo, Bo Yuan.
Experimental and Therapeutic Medicine 2021 Feb; 21(2):103.
Application:Quant, Human, HCT-116 cells, Human foreskin fibroblasts.
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CD24 activates the NLRP3 inflammasome through c-Src kinase activity in a model of the lining epithelium of inflamed periodontal tissues.
Guo W, Ye P, Yu H, Liu Z, Yang P, Hunter H.
Immunity, Inflammation and Disease 2014 Dec; 2(4):239.
Application:ELISA, Human, Porphyromonas gingivalis culture, H413 cells.
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Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis.
Reddy P, Teshima T, Kukuruga M, Ordemann R, Liu C, Lowler K, Ferrara JL.
The Journal of Experimental Medicine 2001 Nov; 194(10):1433.
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Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability.
Mallat Z, Corbaz A, Scoazec A, Besnard S, Lesèche G, Chvatchko Y, Tedgui A.
Circulation 2001 Aug; 104(14):1598.
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Cloning of a new cytokine that induces IFN-gamma production by T cells.
Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al..
Nature 1995 Nov; 378(6552):88.
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Diagnostic Evaluation Using Salivary Gland Ultrasonography in Primary Sjögren's Syndrome.
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