CAP1 monoclonal antibody (M01), clone 4A2
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More Files
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Specifications
Product Description
Mouse monoclonal antibody raised against a full length recombinant CAP1.
Immunogen
CAP1 (AAH13963, 1 a.a. ~ 475 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQKHAEMVHTGLKLERALLVTASQCQQPAENKLSDLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKTGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVSTSSGSDESASRSALFAQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKRATKKEPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (77.99 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CAP1 monoclonal antibody (M01), clone 4A2 Western Blot analysis of CAP1 expression in HeLa ( Cat # L013V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CAP1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — CAP1
Entrez GeneID
10487GeneBank Accession#
BC013963Protein Accession#
AAH13963Gene Name
CAP1
Gene Alias
CAP, CAP1-PEN
Gene Description
CAP, adenylate cyclase-associated protein 1 (yeast)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000004820|OTTHUMP00000004821|OTTHUMP00000004822|adenylyl cyclase-associated protein
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Interactomes
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Diseases
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Publication Reference
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The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex.
Sharof Khudayberdiev, Kerstin Weiss, Anika Heinze, Dalila Colombaretti, Nathan Trausch, Uwe Linne, Marco B Rust.
Sci Signal. 2024 May; 17(835):eadj0032.
Application:ICC, WB, Mouse, DIV6 mouse,DIV10 mouse, P12 mice.
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Expression and function of neuronal growth-associated proteins (nGAPs) in PC12 cells.
Lu J, Nozumi M, Takeuchi K, Abe H, Igarashi M.
Neuroscience Research 2011 May; 70(1):85.
Application:IS, Rat, PC12D cells.
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Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9.
Cauwe B, Martens E, Van den Steen PE, Proost P, Van Aelst I, Blockmans D, Opdenakker G.
Experimental Cell Research 2008 Jul; 314(15):2739.
Application:WB, Human, Urine from patients with systemic autoimmune diseases.
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The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex.
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