ABCC8 monoclonal antibody (M02), clone 3E1
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More Files
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant ABCC8.
Immunogen
ABCC8 (NP_000343, 611 a.a. ~ 710 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTM
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (85); Rat (85)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ABCC8 is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — ABCC8
Entrez GeneID
6833GeneBank Accession#
NM_000352Protein Accession#
NP_000343Gene Name
ABCC8
Gene Alias
ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 8|sulfonylurea receptor (hyperinsulinemia)
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Interactomes
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Pathways
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Diseases
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