ATRX 293T Cell Transient Overexpression Lysate(Denatured)
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Specifications
Transfected Cell Line
293T
Plasmid
pCMV-ATRX full-length
Host
Human
Theoretical MW (kDa)
10.01
Interspecies Antigen Sequence
Mouse (84)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ATRX antibody (H00000546-B01) by Western Blots.
Western Blot
Lane 1: ATRX transfected lysate ( 9.9 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
ATRX transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ATRX
Entrez GeneID
546GeneBank Accession#
BC002521Protein Accession#
AAH02521Gene Name
ATRX
Gene Alias
ATR2, MGC2094, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX
Gene Description
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
DNA dependent ATPase and helicase|OTTHUMP00000024265|OTTHUMP00000062079|X-linked nuclear protein|Zinc finger helicase|helicase 2, X-linked|transcriptional regulator ATRX
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Interactomes
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Diseases
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