GRIA2/GRIA3 recombinant monoclonal antibody, clone 4C3
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human GRIA2/GRIA3.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human GRIA2/GRIA3.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunofluorescence (1:20-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescent staining of MCF-7 cells with GRIA2/GRIA3 recombinant monoclonal antibody, clone 4C3 (Cat # RAB04335) (diluated at 1:56). The secondary antibody was Alexa Fluor 488-congugated goat anti-rabbit IgG (green). Counter-stain DAPI was used (blue).Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRIA2
Entrez GeneID
2891Protein Accession#
P42262;P42263Gene Name
GRIA2
Gene Alias
GLUR2, GLURB, GluR-K2, HBGR2
Gene Description
glutamate receptor, ionotropic, AMPA 2
Omim ID
138247Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000165324|gluR-B|glutamate receptor 2
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Gene Info — GRIA3
Entrez GeneID
2892Protein Accession#
P42262;P42263Gene Name
GRIA3
Gene Alias
GLUR-C, GLUR-K3, GLUR3, GLURC, MRX94
Gene Description
glutamate receptor, ionotrophic, AMPA 3
Omim ID
305915Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq
Other Designations
OTTHUMP00000024261|OTTHUMP00000024262|dJ1171F9.1|glutamate receptor 3|glutamate receptor C|glutamate receptor subunit 3
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