GHR recombinant monoclonal antibody, clone 10C11
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human GHR.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human GHR.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Immunofluorescence(1:20-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of GHR recombinant monoclonal antibody, clone 10C11 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system.Immunofluorescence
Immunofluorescence staining of HepG2 Cells with GHR recombinant monoclonal antibody, clone 10C11 at 1:50, counter-stained with DAPI.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GHR
Entrez GeneID
2690Protein Accession#
P10912Gene Name
GHR
Gene Alias
GHBP
Gene Description
growth hormone receptor
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein
Other Designations
growth hormone binding protein|serum binding protein|somatotropin receptor
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Interactome
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Pathway
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Disease
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