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Western Blot

Immunofluorescence

Immunofluorescent staining of HepG2 cells with ADRB2 recombinant monoclonal antibody, clone 13D6 (Cat # RAB03075).
Immunofluorescence analysis of paraformaldehyde fixed HepG2 cells on Shi-fix™ coverslips stained with the chimeric r version of RAB03075 at 10 ug/ml for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/ml)- showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right- top-bottom RAB03075- DAPI- merged channels and an isotype control. The isotype control was an unknown specificity antibody (.1) followed by staining with Alexa Fluor® 488 secondary antibody.

Immunoprecipitation

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

154

Gene Name

ADRB2

Gene Alias

ADRB2R, ADRBR, B2AR, BAR, BETA2AR

Gene Description

adrenergic, beta-2-, receptor, surface

Omim ID

109690 600807 601665

Gene Ontology

Hyperlink

Gene Summary

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq

Other Designations

beta-2 adrenergic receptor|beta-2 adrenoceptor|catecholamine receptor