ARRB1 recombinant monoclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane1:PC12 whole cell lysate Lane2:Jurkat whole cell lysate with ARRB1 recombinant monoclonal antibody (Cat # RAB02758) at 1:1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung tissue using ARRB1 recombinant monoclonal antibody (Cat # RAB02758).Counter stained with hematoxylin.
Immunocytochemistry
Immunocytochemical staining of A549 cells using ARRB1 recombinant monoclonal antibody (Cat # RAB02758)(green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100/PBS.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against ARRB1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant ARRB1.
Theoretical MW (kDa)
50
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of Arrestin-beta-1 and does not cross-react with related proteins.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50-1:100)
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:100)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.2 (50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane1:PC12 whole cell lysate Lane2:Jurkat whole cell lysate with ARRB1 recombinant monoclonal antibody (Cat # RAB02758) at 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung tissue using ARRB1 recombinant monoclonal antibody (Cat # RAB02758).Counter stained with hematoxylin.Immunocytochemistry
Immunocytochemical staining of A549 cells using ARRB1 recombinant monoclonal antibody (Cat # RAB02758)(green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100/PBS.Immunofluorescence
Flow Cytometry
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Gene Info — ARRB1
Entrez GeneID
408Protein Accession#
P49407Gene Name
ARRB1
Gene Alias
ARB1, ARR1
Gene Description
arrestin, beta 1
Omim ID
107940Gene Ontology
HyperlinkGene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq
Other Designations
arrestin 2|arrestin beta 1
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Interactome
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Pathway
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Disease
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