APP recombinant monoclonal antibody, clone R05-3E3
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More Files
- More Functions
Western Blot
Western blot analysis of Amyloid Precursor Protein in rat Brain, 3T3, Hela lysates using human Amyloid Precursor Protein recombinant monoclonal antibody, clone R05-3E3 (Cat # RAB01709).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin-fixed paraffin-embedded sections) of Human brain with Amyloid Precursor Protein recombinant monoclonal antibody, clone R05-3E3 (Cat # RAB01709).
Immunocytochemistry
Immunocytochemical staining of Hela with Amyloid Precursor Protein recombinant monoclonal antibody, clone R05-3E3 (Cat # RAB01709). (A) Amyloid Precursor Protein (green) and (B) DAPI (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against synthetic peptide of human Amyloid Precursor Protein.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human Amyloid Precursor Protein
Theoretical MW (kDa)
Calculated MW: 87 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:100)
Immunoprecipitation (1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Amyloid Precursor Protein in rat Brain, 3T3, Hela lysates using human Amyloid Precursor Protein recombinant monoclonal antibody, clone R05-3E3 (Cat # RAB01709).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin-fixed paraffin-embedded sections) of Human brain with Amyloid Precursor Protein recombinant monoclonal antibody, clone R05-3E3 (Cat # RAB01709).Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunocytochemical staining of Hela with Amyloid Precursor Protein recombinant monoclonal antibody, clone R05-3E3 (Cat # RAB01709). (A) Amyloid Precursor Protein (green) and (B) DAPI (blue).Immunoprecipitation
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Gene Info — APP
Entrez GeneID
351Protein Accession#
P05067Gene Name
APP
Gene Alias
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gene Description
amyloid beta (A4) precursor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II
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Interactome
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Disease
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