COL1A1 recombinant monoclonal antibody, clone R02-5E5
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More Files
- More Functions
Western Blot
Western blot analysis of Collagen I in A549, HL-60, U2OS lysates using Collagen I antibody.
Immunocytochemistry
Immunocytochemistry staining of HeLa cells with COL1A1 recombinant monoclonal antibody, clone R02-5E5 (Cat # RAB01284).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human COL1A1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human Collagen I.
Theoretical MW (kDa)
Calculated MW: 139 k
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Collagen I in A549, HL-60, U2OS lysates using Collagen I antibody.Immunocytochemistry
Immunocytochemistry staining of HeLa cells with COL1A1 recombinant monoclonal antibody, clone R02-5E5 (Cat # RAB01284).Immunofluorescence
Immunoprecipitation
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Gene Info — COL1A1
Entrez GeneID
1277Protein Accession#
P02452Gene Name
COL1A1
Gene Alias
OI4
Gene Description
collagen, type I, alpha 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish
Other Designations
alpha 1 type I collagen|collagen alpha 1 chain type I|collagen of skin, tendon and bone, alpha-1 chain|pro-alpha-1 collagen type 1|type I collagen alpha 1 chain
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Interactome
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Pathway
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Disease
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