CCR6 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CCR6.
Immunogen
A synthetic peptide corresponding to amino acids 17-36 of human CCR6.
Sequence
DYFVSVNTSYYSVDSEMLLC
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500)
Immunoprecipitation (1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
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Gene Info — CCR6
Entrez GeneID
1235Gene Name
CCR6
Gene Alias
BN-1, CD196, CKR-L3, CKR6, CKRL3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, GPRCY4, STRL22
Gene Description
chemokine (C-C motif) receptor 6
Omim ID
601835Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq
Other Designations
G protein-coupled receptor 29|OTTHUMP00000017618|OTTHUMP00000017619|chemokine (C-C) receptor 6|chemokine receptor-like 3|seven-transmembrane receptor, lymphocyte, 22
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Tracing functional antigen-specific CCR6 Th17 cells after vaccination.
Potzl J, Botteron C, Tausch E, Pedre X, Mueller AM, Mannel DN, Lechner A.
PLoS One 2008 Aug; 3(8):e2951.
Application：Flow Cyt, Mouse, Mouse T cells.
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Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo.
Westphal S, Lugering A, von Wedel J, von Eiff C, Maaser C, Spahn T, Heusipp G, Schmidt MA, Herbst H, Williams IR, Domschke W, Kucharzik T.
The American Journal of Pathology 2008 Mar; 172(3):671.
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Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.
Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi S.
The Journal of Experimental Medicine 2007 Nov; 204(12):2803.
Application：Flow Cyt, Func, Mouse , SKG LN cells.
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Tracing functional antigen-specific CCR6 Th17 cells after vaccination.
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