SMARCA2 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of extract from MDA-MB-435 cells (lane 1) , SW-13 cells (lane 2) , vector transgenic cell SW-13 cells (lane3) , Brm transgenic cell SW-13 cells (lane 4) and BRGI transgenic cell SW-13 cells (lane 5) , using SMARCA2 polyclonal antibody (Cat # PAB8486) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SMARCA2.
Immunogen
A synthetic peptide corresponding to human SMARCA2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-3 ug/mL)
Immunoprecipitation (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western blot analysis of extract from MDA-MB-435 cells (lane 1) , SW-13 cells (lane 2) , vector transgenic cell SW-13 cells (lane3) , Brm transgenic cell SW-13 cells (lane 4) and BRGI transgenic cell SW-13 cells (lane 5) , using SMARCA2 polyclonal antibody (Cat # PAB8486) .Immunoprecipitation
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Gene Info — SMARCA2
Entrez GeneID
6595Gene Name
SMARCA2
Gene Alias
BAF190, BRM, FLJ36757, MGC74511, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a
Gene Description
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Omim ID
600014Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq
Other Designations
OTTHUMP00000020970|OTTHUMP00000020971|SNF2-alpha|SNF2-like 2|SNF2/SWI2-like protein 2|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2|global transcription activator homologous sequence|sucrose nonfermenting 2-like protein 2
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Interactome
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Disease
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Publication Reference
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SWI/SNF chromatin remodelling complex and retroviral gene silencing.
Iba H, Mizutani T, Ito T.
Reviews in Medical Virology 2003 Mar; 13(2):99.
Application：WB, Human, Mammalian cells.
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SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.
Yamamichi-Nishina M, Ito T, Mizutani T, Yamamichi N, Watanabe H, Iba H.
The Journal of Biological Chemistry 2003 Feb; 278(9):7422.
Application：WB-Ce, WB-Tr, Human, SW13, MDA-MB435 cells.
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Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex.
Mizutani T, Ito T, Nishina M, Yamamichi N, Watanabe A, Iba H.
The Journal of Biological Chemistry 2002 May; 277(18):15859.
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SWI/SNF chromatin remodeling and cancer.
Klochendler-Yeivin A, Muchardt C, Yaniv M.
Current Opinion in Genetics & Development 2002 Feb; 12(1):73.
Application：IHC, WB, Human, Lung cancers, Prostate cancers.
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The Swi/Snf family nucleosome-remodeling complexes and transcriptional control.
Sudarsanam P, Winston F.
Trends in Genetics 2000 Aug; 16(8):345.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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SWI/SNF chromatin remodelling complex and retroviral gene silencing.
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