ABCD1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ABCD1.
Immunogen
A synthetic peptide corresponding to human ABCD1.
Sequence
C-EDMQRKGYSEQD
Host
Goat
Theoretical MW (kDa)
82.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 overexpressing human ABCD1 and probed with ABCD1 polyclonal antibody (Cat # PAB7486) at 1ug/ml (mock transfection in first lane).Enzyme-linked Immunoabsorbent Assay
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Gene Info — ABCD1
Entrez GeneID
215Protein Accession#
NP_000024.2Gene Name
ABCD1
Gene Alias
ABC42, ALD, ALDP, AMN
Gene Description
ATP-binding cassette, sub-family D (ALD), member 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq
Other Designations
OTTHUMP00000025960|adrenoleukodystrophy protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Distribution and cellular localization of adrenoleukodystrophy protein in human tissues: implications for X-linked adrenoleukodystrophy.
Hoftberger R, Kunze M, Weinhofer I, Aboul-Enein F, Voigtlander T, Oezen I, Amann G, Bernheimer H, Budka H, Berger J.
Neurobiology of Disease 2007 Nov; 28(2):165.
Application:IF, IHC-P, WB, Human, Human pituitary glands.
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Distribution and cellular localization of adrenoleukodystrophy protein in human tissues: implications for X-linked adrenoleukodystrophy.
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