EXO1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of EXO1.
Immunogen
A synthetic peptide corresponding to human EXO1.
Sequence
C-HRNYSPRPESGT
Host
Goat
Theoretical MW (kDa)
89.1, 94
Reactivity
Human
Specificity
This antibody is expected to recognize all three reported isoforms (NP_0.03677.3, NP_006018.3 and NP_569082.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.2-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
EXO1 polyclonal antibody (Cat # PAB7442) (0.2 ug/mL) staining of A-549 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — EXO1
Entrez GeneID
9156Protein Accession#
NP_0.03677.3;NP_006018.3;NP_569082.1Gene Name
EXO1
Gene Alias
HEX1, hExoI
Gene Description
exonuclease 1
Omim ID
606063Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000037878|OTTHUMP00000037879|rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
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Interactome
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Pathway
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Disease
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Publication Reference
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MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria.
Kim JC, Roh SA, Yoon YS, Kim HC, Park IJ.
Cancer Genetics and Cytogenetics 2007 Jul; 176(2):172.
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MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria.
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