ACVR1C polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACVR1C.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ACVR1C.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of ACVR1C polyclonal antibody (Cat # PAB2641) in HepG2 and Hela cell line lysate (35 ug/lane). ACVR1C (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACVR1C polyclonal antibody (Cat # PAB2641) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — ACVR1C
Entrez GeneID
130399Protein Accession#
NP_660302;Q8NER5Gene Name
ACVR1C
Gene Alias
ACVRLK7, ALK7
Gene Description
activin A receptor, type IC
Omim ID
608981Gene Ontology
HyperlinkGene Summary
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM
Other Designations
activin receptor-like kinase 7
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.
Munir S, Xu G, Wu Y, Yang B, Lala PK, Peng C.
The Journal of Biological Chemistry 2004 Jul; 279(30):31277.
-
Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells.
Kim BC, van Gelder H, Kim TA, Lee HJ, Baik KG, Chun HH, Lee DA, Choi KS, Kim SJ.
The Journal of Biological Chemistry 2004 Jul; 279(27):28458.
-
Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.
Roberts HJ, Hu S, Qiu Q, Leung PC, Caniggia I, Gruslin A, Tsang B, Peng C.
Biology of Reproduction 2003 May; 68(5):1719.
Application:WB-Ti, Human, Placenta.
-
Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com