VLDLR (Human) Recombinant Protein
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More Files
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Surface Plasmon Resonance
Human VLDLR, His Tag immobilized on CM5 Chip can bind Human PCSK9, His Tag with an affinity constant of 0.72 nM as determined in SPR assay (Biacore T200).
SEC-HPLC
The purity of Human VLDLR is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human VLDLR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human VLDLR (P98155-1, Gly28-Ser797) partial recombinant protein with His tag at C-Terminus expressed in HEK293 cells.
Sequence
Gly28-Ser797
Host
Human
Theoretical MW (kDa)
85.90000000000001
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The affinity constant of 0.72 nM as determined in SPR assay (Biacore T200).
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human VLDLR is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human VLDLR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
SDS-PAGE
SPR
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Functional Study
SDS-PAGE
Surface Plasmon Resonance
Human VLDLR, His Tag immobilized on CM5 Chip can bind Human PCSK9, His Tag with an affinity constant of 0.72 nM as determined in SPR assay (Biacore T200). -
Gene Info — VLDLR
Entrez GeneID
7436Protein Accession#
P98155-1Gene Name
VLDLR
Gene Alias
CHRMQ1, FLJ35024, VLDLRCH
Gene Description
very low density lipoprotein receptor
Gene Ontology
HyperlinkGene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000020982|OTTHUMP00000020983|Very low-density lipoprotein receptor
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Interactome
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Disease
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