TNFRSF13B (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF13B (O14836-1, Ser2-Thr166) partial recombinant protein with hFc tag at C-terminus expressed in HEK293 cells.
Sequence
Ser2-Thr166
Host
Human
Theoretical MW (kDa)
45.3
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The EC50 was 3.0 ng/mL, messured by ELISA at 1 ug/mL.
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human TACI is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human TACI on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -81°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human BAFF Trimer, His Tag at 1 ug/mL (100 uL/well) on the plate. Dose response curve for Human TACI, hFc Tag with the EC50 of 3.0 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — TNFRSF13B
Entrez GeneID
23495Protein Accession#
O14836-1Gene Name
TNFRSF13B
Gene Alias
CD267, CVID, FLJ39942, MGC133214, MGC39952, TACI, TNFRSF14B
Gene Description
tumor necrosis factor receptor superfamily, member 13B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq
Other Designations
OTTHUMP00000065442|transmembrane activator and CAML interactor|tumor necrosis factor receptor 13B
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