FCER1A (Human) Recombinant Protein
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More Files
- More Functions
Enzyme-linked Immunoabsorbent Assay
Immobilized Human Fc epsilon RI alpha, His Tag at 0.2 ug/mL (100 uL/well) on the plate. Dose response curve for Anti-Fc epsilon RI alpha Antibody , hFc Tag with the EC50 of 14.1 ng/mL determined by ELISA.
SEC-HPLC
The purity of Human Fc epsilon RI alpha is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human Fc epsilon RI alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human FCER1A (P12319-1, Val26-Gln205) partial recombinant protein with His tag at C-Terminus expressed in HEK293 cells.
Sequence
Val26-Gln205
Host
Human
Theoretical MW (kDa)
22.1
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human Fc epsilon RI alpha is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human Fc epsilon RI alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human Fc epsilon RI alpha, His Tag at 0.2 ug/mL (100 uL/well) on the plate. Dose response curve for Anti-Fc epsilon RI alpha Antibody , hFc Tag with the EC50 of 14.1 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — FCER1A
Entrez GeneID
2205Protein Accession#
P12319-1Gene Name
FCER1A
Gene Alias
FCE1A, FcERI
Gene Description
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Omim ID
147140Gene Ontology
HyperlinkGene Summary
The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM
Other Designations
Fc IgE receptor, alpha polypeptide|Fc epsilon RI alpha-chain|Fc-epsilon RI-alpha|high affinity immunoglobulin epsilon receptor alpha-subunit|immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
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Interactome
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Pathway
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Disease
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