CD46 (Human) Recombinant Protein

Catalog # P9088

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Size:20 ug
Price: USD $ 216.00
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  • +1-909-264-1399
    +1-909-992-0619
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  • Specifications

    Product Description

    Human CD46 (P15529, 35 a.a. - 313 a.a.) partial-length recombinant protein with His tag at N-Terminus expressed in Escherichia coli.

    Sequence

    MGSSHHHHHHSSGLVPRGSHMGSCEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVSNYPGYPKPEEGILDSLD.

    Host

    Escherichia coli

    Theoretical MW (kDa)

    33.8

    Form

    Liquid

    Preparation Method

    Escherichia coli expression system

    Purity

    > 85% by SDS-PAGE.

    Storage Buffer

    20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 20% glycerol.

    Storage Instruction

    Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.

  • Applications

    SDS-PAGE

  • Gene Info — CD46

    Entrez GeneID

    4179

    Protein Accession#

    P15529

    Gene Name

    CD46

    Gene Alias

    MCP, MGC26544, MIC10, TLX, TRA2.10

    Gene Description

    CD46 molecule, complement regulatory protein

    Omim ID

    120920 235400

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    CD46 antigen, complement regulatory protein|OTTHUMP00000034577|OTTHUMP00000034622|OTTHUMP00000034623|OTTHUMP00000034624|OTTHUMP00000034625|OTTHUMP00000034626|OTTHUMP00000034706|antigen identified by monoclonal antibody TRA-2-10|complement membrane cofacto

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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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