APOB (Human) Recombinant Protein
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Specification
Product Description
Human APOB (P04114) isolation from Human plasma.
Host
Human
Theoretical MW (kDa)
550
Form
Lyophilized
Preparation Method
Human Plasma.
Purity
> 95% by SDS-PAGE
Storage Buffer
Lyophilized from 50mM Na2CO3 pH 10 containing 50mM NaCl and 10mM sodium deoxycholate
Storage Instruction
Upon reconstitution should be stored at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — APOB
Entrez GeneID
338Protein Accession#
P04114Gene Name
APOB
Gene Alias
FLDB
Gene Description
apolipoprotein B (including Ag(x) antigen)
Gene Ontology
HyperlinkGene Summary
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq
Other Designations
OTTHUMP00000115994|apoB-100|apoB-48|apolipoprotein B|apolipoprotein B48
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