CD86 (Human) Recombinant Protein
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Specification
Product Description
Human CD86 (26 a.a. - 247 a.a.) partial recombinant protein with a Fc tag at the C-terminus expressed in HEK293 cells.
Host
Human
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Protein A purification
Purity
> 95% (determined by SDS-PAGE)
Activity
ELISA plate pre-coated by 2 ug/mL (100 uL/well) human CD86, hFc tagged protein can bind human CTLA4, mFc-His tagged protein in a linear range of 0.048-2.694 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4 (5-82% Trehalose).
Storage Instruction
Store at -80°C on dry atmosphere, lyophilized antibodies are stable at least 2 years.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — CD86
Entrez GeneID
942Protein Accession#
P42081Gene Name
CD86
Gene Alias
B7-2, B70, CD28LG2, LAB72, MGC34413
Gene Description
CD86 molecule
Omim ID
601020Gene Ontology
HyperlinkGene Summary
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq
Other Designations
B-lymphocyte activation antigen B7-2|B7-2 antigen|CD28 antigen ligand 2|CD86 antigen|CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)|CTLA-4 counter-receptor B7.2
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