Products

Functional Study

Entrez GeneID

Protein Accession#

Gene Name

CDK9

Gene Alias

C-2k, CDC2L4, CTK1, PITALRE, TAK

Gene Description

cyclin-dependent kinase 9

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq

Other Designations

CDC2-related kinase|OTTHUMP00000022198|cell division protein kinase 9|serine/threonine protein kinase PITALRE

Entrez GeneID

Protein Accession#

Gene Name

CCNK

Gene Alias

CPR4, MGC9113

Gene Description

cyclin K

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq

Other Designations

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