LGR4 monoclonal antibody, clone 12H6
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant LGR4.
Immunogen
Recombinant protein corresponding to full length human LGR4.
Host
Mouse
Reactivity
Human
Form
Liquid
Recommend Usage
Flow Cyt (1-5 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2% Block Ace)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Flow Cytometry
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Gene Info — LGR4
Entrez GeneID
55366Gene Name
LGR4
Gene Alias
GPR48
Gene Description
leucine-rich repeat-containing G protein-coupled receptor 4
Omim ID
606666Gene Ontology
HyperlinkGene Summary
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM
Other Designations
G protein-coupled receptor 48|G-protein-coupled receptor 48
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Interactome
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Pathway
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Publication Reference
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Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.
Gao Y, Kitagawa K, Hiramatsu Y, Kikuchi H, Isobe T, Shimada M, Uchida C, Hattori T, Oda T, Nakayama K, Nakayama KI, Tanaka T, Konno H, Kitagawa M.
Cancer Research 2006 Dec; 66(24):11623.
Application:IHC-P, Human, Colon carcinoma.
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LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice.
Hoshii T, Takeo T, Nakagata N, Takeya M, Araki K, Yamamura K.
Biology of Reproduction 2007 Feb; 76(2):303.
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Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality.
Mazerbourg S, Bouley DM, Sudo S, Klein CA, Zhang JV, Kawamura K, Goodrich LV, Rayburn H, Tessier-Lavigne M, Hsueh AJ.
Molecular Endocrinology (Baltimore, Md.) 2004 Sep; 18(9):2241.
Application:IHC-P, Mouse, Mouse kidney.
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Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.
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