LBP monoclonal antibody, clone biG 48
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant LBP.
Immunogen
Recombinant protein corresponding to human LBP.
Host
Mouse
Reactivity
Human
Specificity
No inhibition of LPS binding to membrane bound CD14.
Form
Lyophilized
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
LBP inhibition studies
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.2.
Storage Instruction
The lyophilized product thought stable room temperature up to 3 weeks, but is best stored desiccated at -80°C more than 1 year, at refrigerator about 10 months.
After reconstitution with 100 uL of sterile ultra-pure distilled water, reconstituted protein should be used immediately or stored in undiluted working aliquots at -20°C. For long term storage it is recommended to add a carrier protein (0.1% BSA).
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — LBP
Entrez GeneID
3929Gene Name
LBP
Gene Alias
MGC22233
Gene Description
lipopolysaccharide binding protein
Omim ID
151990Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq
Other Designations
LPS-binding protein|OTTHUMP00000030965|lipopolysaccharide-binding protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms.
Mingqian Fang, Yu Li, Zhiyi Liao, Gan Wang, Qiqi Cao, Ya Li, Yong Duan, Yanbing Han, Xinyi Deng, Feilong Wu, Peter Muiruri Kamau, Qiumin Lu, Ren Lai.
Immunity 2023 Mar; 56(3):620.
Application:Co-IP, IF, Human, Human serum, SH-SY5Y cells.
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Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptors.
Ogawa T, Asai Y, Hashimoto M, Uchida H.
European Journal of Immunology 2002 Sep; 32(9):2543.
Application:Pretreated, Recombinant protein.
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Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms.
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