PRLR monoclonal antibody, clone SPM213
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Specification
Product Description
Mouse monoclonal antibody raised against native human PRLR.
Immunogen
Semi-purified human PRLR.
Host
Mouse
Theoretical MW (kDa)
70
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testicle tumor with PRLR monoclonal antibody, clone SPM213 (Cat # MAB15206).Immunofluorescence
Flow Cytometry
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Gene Info — PRLR
Entrez GeneID
5618Protein Accession#
P16471Gene Name
PRLR
Gene Alias
hPRLrI
Gene Description
prolactin receptor
Omim ID
176761Gene Ontology
HyperlinkOther Designations
OTTHUMP00000115998|delta 4-SF1b truncated prolactin receptor|delta 4-delta 7/11 truncated prolactin receptor|hPRL receptor|prolactin receptor delta 7/11|secreted prolactin binding protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Prolactin receptor is a negative prognostic factor in patients with squamous cell carcinoma of the head and neck.
Bauernhofer T, Pichler M, Wieckowski E, Stanson J, Aigelsreiter A, Griesbacher A, Groselj-Strele A, Linecker A, Samonigg H, Langner C, Whiteside TL.
British Journal of Cancer 2011 May; 104(10):1641.
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Amplification of the prolactin receptor gene in mammary lobular neoplasia.
Tran-Thanh D, Arneson NC, Pintilie M, Deliallisi A, Warren KS, Bane A, Done SJ.
Breast Cancer Research and Treatment 2011 Jul; 128(1):31.
Application:IHC-P, Human, Human mammary lobular neoplasia.
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Clinicopathological significance of prolactin receptor expression in colorectal carcinoma and corresponding metastases.
Harbaum L, Pollheimer MJ, Bauernhofer T, Kornprat P, Lindtner RA, Schlemmer A, Rehak P, Langner C.
Modern Pathology 2010 Jul; 23(7):961.
Application:ICC, IHC-P, WB-Ce, Human, HT-29 cells, Human colorectal carcinoma, SW480 cells, T-47D cells.
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Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.
Howell SJ, Anderson E, Hunter T, Farnie G, Clarke RB.
Breast Cancer Research 2008 Aug; 10(4):R68.
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Prolactin receptor expression in gynaecomastia and male breast carcinoma.
Ferreira M, Mesquita M, Quaresma M, André S.
Histopathology 2008 Jul; 53(1):56.
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Prolactin receptor is a negative prognostic factor in patients with squamous cell carcinoma of the head and neck.
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