IL1B (Human) ELISA Kit
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Specification
Product Description
IL1B (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human IL1B.
Suitable Sample
Cell Culture Supernatant, Plasma (Citrate, EDTA, Heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
3.9 to 250 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — IL1B
Entrez GeneID
3553Gene Name
IL1B
Gene Alias
IL-1, IL1-BETA, IL1F2
Gene Description
interleukin 1, beta
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq
Other Designations
catabolin|preinterleukin 1 beta|pro-interleukin-1-beta
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Interactome
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Pathway
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Disease
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Publication Reference
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Exosomal Mir-3613-3p derived from oxygen-glucose deprivation-treated brain microvascular endothelial cell promotes microglial M1 polarization.
Mengqi Zhang, Qian Wu, Mimi Tang, Zhuohui Chen, Haiyue Wu.
Cellular & Molecular Biology Letters 2023 Mar; 28(1):18.
Application:Quant, Human, Human brain microvascular endothelial cells.
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IFN-γ and IL-18 in conditioned media of parasite-infected host and IL-21-silenced colorectal cancer cells.
Peng Ge, Ching Yi Ong, Abdalla Eshtiyag Abdalkareem, Boon Yin Khoo, Bo Yuan.
Experimental and Therapeutic Medicine 2021 Feb; 21(2):103.
Application:Quant, Human, HCT-116 cells, Human foreskin fibroblasts.
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IL-1β from M2 macrophages promotes migration and invasion of ESCC cells enhancing epithelial-mesenchymal transition and activating NF-κB signaling pathway.
Zhou J, Zheng S, Liu T, Liu Q, Chen Y, Tan D, Ma R, Lu X.
Journal of Cellular Biochemistry 2018 Aug; 119(8):7040.
Application:ELISA, Human, Eca109, KYSE-150 cells supernatant.
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CD24 activates the NLRP3 inflammasome through c-Src kinase activity in a model of the lining epithelium of inflamed periodontal tissues.
Guo W, Ye P, Yu H, Liu Z, Yang P, Hunter H.
Immunity, Inflammation and Disease 2014 Dec; 2(4):239.
Application:ELISA, Human, Porphyromonas gingivalis culture, H413 cells.
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Meniscal tear as potential steering factor for inflammation may aggravate arthritis: two case reports.
Kulkarni P, Koppikar S, Deshpande S, Wagh N, Harsulkar A.
Journal of Medical Case Reports 2014 May; 8:137.
Application:ELISA, Human, Synovial fluid.
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Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity.
Takahashi JL, Giuliani F, Power C, Imai Y, Yong VW.
Annals of Neurology 2003 May; 53(5):588.
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IL-1 is required for tumor invasiveness and angiogenesis.
Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, Dinarello CA, Apte RN.
PNAS 2003 Mar; 100(5):2645.
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Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.
Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG.
Cell 2002 Jul; 110(1):55.
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Exosomal Mir-3613-3p derived from oxygen-glucose deprivation-treated brain microvascular endothelial cell promotes microglial M1 polarization.
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