SEPT12 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human SEPT12 protein.
Immunogen
SEPT12 (AAH35619.1, 1 a.a. ~ 358 a.a) full-length human protein.
Sequence
MDPLRRSPSPCLSSQPSSPSTPPCEMLGPVGIEAVLDQLKIKAMKMGFEFNIMVVGQSGLGKSTMVNTLFKSKVWKSNPPGLGVPTPQTLQLHSLTHVIEEKGVKLKLTVTDTPGFGDQINNDNCWDPILGYINEQYEQYLQEEILITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLQRLCRTVNVVPVIARADSLTMEEREAFRRRIQQNLRTHCIDVYPQMCFDEDINDKILNSKLRDRIPFAVVGADQEHLVNGRCVLGRKTKWGIIEVENMAHCEFPLLRDLLIRSHLQDLKDITHNIHYENYRVIRLNESHLLPRGPGWVNLAPASPGQLTTPRTFKVCRGAHDDSDDEF
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (87); Rat (85)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of SEPT12 expression in transfected 293T cell line (H00124404-T01) by SEPT12 MaxPab polyclonal antibody.
Lane 1: SEPT12 transfected lysate(39.38 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to SEPT12 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]Immunofluorescence
Immunofluorescence of purified MaxPab antibody to SEPT12 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — SEPT12
Entrez GeneID
124404GeneBank Accession#
BC035619Protein Accession#
AAH35619.1Gene Name
SEPT12
Gene Alias
FLJ25410
Gene Description
septin 12
Omim ID
611562Gene Ontology
HyperlinkGene Summary
Septins, such as SEPT12, are conserved GTP-binding proteins that function as dynamic, regulatable scaffolds for the recruitment of other proteins. They are involved in membrane dynamics, vesicle trafficking, apoptosis, and cytoskeleton remodeling, as well as infection, neurodegeneration, and neoplasia (Hall et al., 2005 [PubMed 15915442]).[supplied by OMIM
Other Designations
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Interactome
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Publication Reference
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The SEPT12 complex is required for the establishment of a functional sperm head-tail junction.
Yi-Ru Shen, Han-Yu Wang, Yung-Chieh Tsai, Yung-Che Kuo, Shang-Rung Wu, Chia-Yih Wang, Pao-Lin Kuo.
Molecular Human Reproduction 2020 Jun; 26(6):402.
Application:IF, Human, Mature spermatozoa.
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Low dose lead exposure at the onset of puberty disrupts spermatogenesis-related gene expression and causes abnormal spermatogenesis in mouse.
Xie J, Yu J, Fan Y, Zhao X, Su J, Meng Y, Wu Y, Uddin MB, Wang C, Wang Z.
Toxicology and Applied Pharmacology 2020 Apr; 393:114942.
Application:WB-Ti, Mouse, Testis, Epididymis tissues.
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Single-nucleotide polymorphism c.474G>A in the SEPT12 gene is a predisposing factor in male infertility.
Rafaee A, Mohseni Meybodi A, Yaghmaei P, Hosseini SH, Sabbaghian M.
Molecular Reproduction and Development 2020 Feb; 87(2):251.
Application:IF, WB-Ce, Human, Human spermatozoa.
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Testis-Specific SEPT12 Expression Affects SUN Protein Localization and is Involved in Mammalian Spermiogenesis.
Chung-Hsin Yeh, Ya-Yun Wang, Shi-Kae Wee, Mei-Feng Chen, Han-Sun Chiang, Pao-Lin Kuo, Ying-Hung Lin.
International Journal of Molecular Sciences 2019 Mar; 20(5):1163.
Application:IF, Mouse, Mouse spermatids.
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Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.
Kuo PL, Tseng JY, Chen HI, Wu CY, Omar HA, Wang CY, Cheng HY, Hsu CC, Fu TF, Teng YN.
Biochimie 2018 Dec; 158:1.
Application:WB, Human, NT2/D1 cells.
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CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization.
Huang CY, Wang YY, Chen YL, Chen MF, Chiang HS, Kuo PL, Lin YH.
International Journal of Molecular Sciences 2018 Sep; 19(9):E2627.
Application:IF, Mouse, Germ cells.
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SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.
Lai TH, Wu YY, Wang YY, Chen MF, Wang P, Chen TM, Wu YN, Chiang HS, Kuo PL, Lin YH.
International Journal of Molecular Sciences 2016 Nov; 17(11).
Application:IF, Human, Human semen.
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SEPT12-Microtubule Complexes Are Required for Sperm Head and Tail Formation.
Kuo PL, Chiang HS, Wang YY, Kuo YC, Chen MF, Yu IS, Teng YN, Lin SW, Lin YH.
International Journal of Molecular sciences 2013 Nov; 14(11):22102.
Application:IF, WB-Tr, Human, NTERA-2 d.D1 cells.
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SEPTIN12 genetic variants confer susceptibility to teratozoospermia.
Lin YH, Wang YY, Chen HI, Kuo YC, Chiou YW, Lin HH, Wu CM, Hsu CC, Chiang HS, Kuo PL.
PLoS One 2012 Mar; 7(3):e34011.
Application:IF, Human, Human spermatozoa.
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SEPT12 mutations cause male infertility with defective sperm annulus.
Kuo YC, Lin YH, Chen HI, Wang YY, Chiou YW, Lin HH, Pan HA, Wu CM, Su SM, Hsu CC, Kuo PL.
Human Mutation 2012 Apr; 33(4):710.
Application:IF, Human, Human spermatozoa.
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The SEPT12 complex is required for the establishment of a functional sperm head-tail junction.
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