NOG purified MaxPab mouse polyclonal antibody (B01P)

Catalog # H00009241-B01P

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Size:50 ug
Price: USD $ 335.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Western Blot (Transfected lysate)
Application

Western Blot (Transfected lysate)

Western Blot analysis of NOG expression in transfected 293T cell line (H00009241-T01) by NOG MaxPab polyclonal antibody.

Lane 1: NOG transfected lysate(25.52 KDa).
Lane 2: Non-transfected lysate.

  • Specifications

    Product Description

    Mouse polyclonal antibody raised against a full-length human NOG protein.MaxPab Polyclonal Antibody,MaxPab Polyclonal Antibodies,MaxPab,DNA Immune,DNA Immunization,Immune Technology

    Immunogen

    NOG (NP_005441.1, 1 a.a. ~ 232 a.a) full-length human protein.

    Sequence

    MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC

    Host

    Mouse

    Reactivity

    Human

    Interspecies Antigen Sequence

    Mouse (99); Rat (99)

    Quality Control Testing

    Antibody reactive against mammalian transfected lysate.

    Storage Buffer

    In 1x PBS, pH 7.4

    Storage Instruction

    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

  • Applications

    Western Blot (Transfected lysate)

    Western Blot analysis of NOG expression in transfected 293T cell line (H00009241-T01) by NOG MaxPab polyclonal antibody.

    Lane 1: NOG transfected lysate(25.52 KDa).
    Lane 2: Non-transfected lysate.
  • Gene Info — NOG

    Entrez GeneID

    9241

    GeneBank Accession#

    NM_005450

    Protein Accession#

    NP_005441.1

    Gene Name

    NOG

    Gene Alias

    SYM1, SYNS1

    Gene Description

    noggin

    Omim ID

    184460 185800 186500 186570 602991

    Gene Ontology

    Hyperlink

    Gene Summary

    The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq

    Other Designations

    symphalangism 1 (proximal)

  • Interactomes
  • Pathways
  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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