TYK2 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-TYK2 full-length
Host
Human
Theoretical MW (kDa)
133.7
Interspecies Antigen Sequence
Mouse (78); Rat (80)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-TYK2 antibody (H00007297-D01P) by Western Blots.
SDS-PAGE Gel
TYK2 transfected lysate.
Western Blot
Lane 1: TYK2 transfected lysate ( 133.70 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — TYK2
Entrez GeneID
7297GeneBank Accession#
NM_003331.3Protein Accession#
NP_003322.2Gene Name
TYK2
Gene Alias
JTK1
Gene Description
tyrosine kinase 2
Omim ID
176941Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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