PTPRC (Human) Recombinant Protein (Q01)

Catalog # H00005788-Q01

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Size:25 ug
Price: USD $ 510.00
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  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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  • Specifications

    Product Description

    Human PTPRC partial ORF ( NP_002829.2, 1207 a.a. - 1304 a.a.) recombinant protein with GST-tag at N-terminal.

    Sequence

    PGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS

    Host

    Wheat Germ (in vitro)

    Theoretical MW (kDa)

    36.52

    Interspecies Antigen Sequence

    Mouse (62); Rat (64)

    Preparation Method

    in vitro wheat germ expression system

    Purification

    Glutathione Sepharose 4 Fast Flow

    Quality Control Testing

    12.5% SDS-PAGE Stained with Coomassie Blue.

    Storage Buffer

    50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

    Storage Instruction

    Store at -80°C. Aliquot to avoid repeated freezing and thawing.

    Note

    Best use within three months from the date of receipt of this protein.

  • Applications

    Enzyme-linked Immunoabsorbent Assay

    Western Blot (Recombinant protein)

    Antibody Production

    Protein Array

  • Gene Info — PTPRC

    Entrez GeneID

    5788

    GeneBank Accession#

    NM_002838

    Protein Accession#

    NP_002829.2

    Gene Name

    PTPRC

    Gene Alias

    B220, CD45, CD45R, GP180, LCA, LY5, T200

    Gene Description

    protein tyrosine phosphatase, receptor type, C

    Omim ID

    126200 151460 609532

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq

    Other Designations

    CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|glycoprotein|leukocyte-common antigen|protein tyrosine phosphatase, receptor type, c polypeptide

  • Interactomes
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  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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