MS4A2 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-MS4A2 full-length
Host
Human
Theoretical MW (kDa)
26.5
Interspecies Antigen Sequence
Mouse (58); Rat (55)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-MS4A2 antibody (H00002206-D01P) by Western Blots.
SDS-PAGE Gel
MS4A2 transfected lysate.
Western Blot
Lane 1: MS4A2 transfected lysate ( 26.50 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — MS4A2
Entrez GeneID
2206GeneBank Accession#
NM_000139Protein Accession#
NP_000130.1Gene Name
MS4A2
Gene Alias
APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1
Gene Description
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
Gene Ontology
HyperlinkGene Summary
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members. Alternative splicing results in multiple transcript variants encoding different isoforms
Other Designations
Fc IgE receptor, beta chain|Fc epsilon receptor I beta-chain|Fc-epsilon receptor I beta-chain|High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)|IgE responsiveness (atopic)
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Interactome
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Pathway
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Disease
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