ETV6 monoclonal antibody (M01), clone 3B10
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant ETV6.
Immunogen
ETV6 (AAH43399, 1 a.a. ~ 452 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (89); Rat (95)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (75.46 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
ETV6 monoclonal antibody (M01), clone 3B10 Western Blot analysis of ETV6 expression in Jurkat ( Cat # L017V1 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to ETV6 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ETV6 is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — ETV6
Entrez GeneID
2120GeneBank Accession#
BC043399Protein Accession#
AAH43399Gene Name
ETV6
Gene Alias
TEL, TEL/ABL
Gene Description
ets variant 6
Gene Ontology
HyperlinkGene Summary
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq
Other Designations
TEL oncogene|TEL1 oncogene|ets variant gene 6 (TEL oncogene)
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Interactome
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Pathway
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Disease
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Publication Reference
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ETV6 mutations in early immature human T cell leukemias.
Van Vlierberghe P, Ambesi-Impiombato A, Perez-Garcia A, Haydu JE, Rigo I, Hadler M, Tosello V, Della Gatta G, Paietta E, Racevskis J, Wiernik PH, Luger SM, Rowe JM, Rue M, Ferrando AA.
The Journal of Experimental Medicine 2011 Dec; 208(13):2571.
Application:WB, Human, LOUCY cells, Primary adult T cell acute lymphoblastic leukemias (T-ALLs) samples.
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The ETS Family Member TEL Binds to Nuclear Receptors RAR and RXR and Represses Gene Activation.
Meester-Smoor MA, Janssen MJ, Ter Haar WM, van Wely KH, Aarnoudse AJ, van Oord G, van Tilburg GB, Zwarthoff EC.
PLoS One 2011 Sep; 6(9):e23620.
Application:WB-Re, Human, Recombinant proteins.
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ETV6 mutations in early immature human T cell leukemias.
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