ARNTL (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ARNTL full-length ORF ( AAH41129, 1 a.a. - 625 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQESMDTDKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIHRIRGSSPSSCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIGIDMIDNDQGSSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
94.49
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ARNTL
Entrez GeneID
406GeneBank Accession#
BC041129Protein Accession#
AAH41129Gene Name
ARNTL
Gene Alias
BMAL1, BMAL1c, JAP3, MGC47515, MOP3, PASD3, TIC, bHLHe5
Gene Description
aryl hydrocarbon receptor nuclear translocator-like
Omim ID
602550Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ARNT-like protein 1, brain and muscle|bHLH-PAS protein JAP3|basic-helix-loop-helix-PAS orphan MOP3|member of PAS superfamily 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
Ilaria Barone, Nicole M Gilette, Hannah Hawks-Mayer, Jonathan Handy, Kevin J Zhang, Fortunate F Chifamba, Engie Mostafa, Erin M Johnson-Venkatesh, Yan Sun, Jennifer M Gibson, Alexander Rotenberg, Hisashi Umemori, Peter T Tsai, Jonathan O Lipton.
Science Advances 2023 Oct; 9(43):eadj1010.
Application:KA, N/A, Recombinant proteins.
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The circadian clock regulator Bmal1 affects traumatic brain injury in rats through the p38 MAPK signalling pathway.
Bing Li, Di Li, Haibo Ni, Chenglin Liu, Jian Xiong, Huixiang Liu, Rong Gao, Li Zhang, Gang Chen.
Brain Research Bulletin 2022 Jan; 178:17.
Application:Stimulation, Rat, Rat brain.
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Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.
Petkau N, Budak H, Zhou X, Oster H, Eichele G.
Elife 2019 Jul; 8:e43235.
Application:Func, PI, WB-Re, Recombinant protein.
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A Pit-1 Binding Site Adjacent to E-box133 in the Rat PRL Promoter is Necessary for Pulsatile Gene Expression Activity.
Bose S, Ganguly S, Kumar S, Boockfor FR.
Amino Acids 2016 Feb; 41(6):1390.
Application:Func, Oligos.
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Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
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