ABCD1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ABCD1 full-length
Host
Human
Theoretical MW (kDa)
82.9
Interspecies Antigen Sequence
Mouse (92); Rat (91)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ABCD1 antibody (H00000215-D01) by Western Blots.
SDS-PAGE Gel
ABCD1 transfected lysate.
Western Blot
Lane 1: ABCD1 transfected lysate ( 82.90 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ABCD1
Entrez GeneID
215GeneBank Accession#
NM_000033.2Protein Accession#
NP_000024.2Gene Name
ABCD1
Gene Alias
ABC42, ALD, ALDP, AMN
Gene Description
ATP-binding cassette, sub-family D (ALD), member 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq
Other Designations
OTTHUMP00000025960|adrenoleukodystrophy protein
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Interactome
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Pathway
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Disease
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