PRKCZ & GRM5 Protein Protein Interaction Antibody Pair

Catalog # DI0235

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Size:1 Set
Price: USD $ 552.00
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  • +1-909-264-1399
    +1-909-992-0619
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  • +1-909-992-3401
Images
QC Test

Representative image of Proximity Ligation Assay of protein-protein interactions between PRKCZ and GRM5. HeLa cells were stained with anti-PRKCZ rabbit purified polyclonal antibody 1:1200 and anti-GRM5 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.

  • Specifications

    Product Description

    This protein protein interaction antibody pair set comes with two antibodies to detect the protein-protein interaction, one against the PRKCZ protein, and the other against the GRM5 protein for use in in situ Proximity Ligation Assay. See Publication Reference below.

    Reactivity

    Human

    Quality Control Testing

    Protein protein interaction immunofluorescence result.

    Representative image of Proximity Ligation Assay of protein-protein interactions between PRKCZ and GRM5. HeLa cells were stained with anti-PRKCZ rabbit purified polyclonal antibody 1:1200 and anti-GRM5 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex. The images were analyzed using an optimized freeware (BlobFinder) download from The Centre for Image Analysis at Uppsala University.

    Supplied Product

    Antibody pair set content:
    1. PRKCZ rabbit purified polyclonal antibody (100 ug)
    2. GRM5 mouse monoclonal antibody (40 ug)
    *Reagents are sufficient for at least 30-50 assays using recommended protocols.

    Storage Instruction

    Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.

  • Applications

    In situ Proximity Ligation Assay (Cell)

  • Gene Info — GRM5

    Entrez GeneID

    2915

    Gene Name

    GRM5

    Gene Alias

    GPRC1E, MGLUR5, mGlu5

    Gene Description

    glutamate receptor, metabotropic 5

    Omim ID

    604102

    Gene Ontology

    Hyperlink

    Gene Summary

    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    -

  • Gene Info — PRKCZ

    Entrez GeneID

    5590

    Gene Name

    PRKCZ

    Gene Alias

    PKC-ZETA, PKC2

    Gene Description

    protein kinase C, zeta

    Omim ID

    176982

    Gene Ontology

    Hyperlink

    Gene Summary

    Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq

    Other Designations

    OTTHUMP00000001368|OTTHUMP00000044160

  • Interactomes
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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