HMGCS2 recombinant monoclonal antibody, clone 19C11
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human HMGCS2.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human HMGCS2.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography purification
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry(1:50-1:200)
Western Blot(1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150 mM NaCl, 0.02% sodium azide and 50% glycerol)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: A549 whole cell lysate; Lane 2: Ntera-2 whole cell lysate.Immunohistochemistry
Immunohistochemistry image of HMGCS2 recombinant monoclonal antibody, clone 19C11 diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HMGCS2
Entrez GeneID
3158Protein Accession#
P54868Gene Name
HMGCS2
Gene Alias
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Gene Description
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
Gene Ontology
HyperlinkGene Summary
Mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase (HMGCS2; EC 2.3.3.10) mediates the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for brain, heart, kidney, and other organs during times of carbohydrate deprivation such as fasting (Robinson and Williamson, 1980 [PubMed 6986618]). Also see cytoplasmic HMG-CoA synthase (HMGCS1; MIM 142940), which mediates an early step in cholesterol synthesis.[supplied by OMIM
Other Designations
OTTHUMP00000013928|hydroxymethylglutaryl-CoA synthase 2
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Interactome
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