NRG3 recombinant monoclonal antibody, clone R02-9E5
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More Files
- More Functions
Western Blot
Western blot analysis of K562, rat brain lysates with NRG3 recombinant monoclonal antibody, clone R02-9E5 (Cat # RAB04920).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human NRG3.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human NRG3.
Theoretical MW (kDa)
Calculated MW: 78 kD
Reactivity
Human, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of K562, rat brain lysates with NRG3 recombinant monoclonal antibody, clone R02-9E5 (Cat # RAB04920). -
Gene Info — NRG3
Entrez GeneID
10718Protein Accession#
P56975Gene Name
NRG3
Gene Alias
HRG3, pro-NRG3
Gene Description
neuregulin 3
Omim ID
605533Gene Ontology
HyperlinkGene Summary
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified
Other Designations
neuregulin-3-like polypeptide
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Interactome
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Pathway
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Disease
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