PSENEN recombinant monoclonal antibody, clone R08-5F0
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: Raw 264.7 whole cell lysate and Lane 2: mouse brain tissue with PSENEN recombinant monoclonal antibody, clone R08-5F0 (Cat # RAB04474).
Immunocytochemistry
Immunocytochemistry staining of HeLa cells with PSENEN recombinant monoclonal antibody, clone R08-5F0 (Cat # RAB04474) (green). DAPI was stained the cell nucleus (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PSENEN.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human PSENEN.
Theoretical MW (kDa)
Calculated MW: 12 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, 150mM NaCl, pH 7.4 (40% glycerol, 0.05% BSA and 0.01% Sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: Raw 264.7 whole cell lysate and Lane 2: mouse brain tissue with PSENEN recombinant monoclonal antibody, clone R08-5F0 (Cat # RAB04474).Immunohistochemistry
Immunocytochemistry
Immunocytochemistry staining of HeLa cells with PSENEN recombinant monoclonal antibody, clone R08-5F0 (Cat # RAB04474) (green). DAPI was stained the cell nucleus (blue).Immunofluorescence
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Gene Info — PSENEN
Entrez GeneID
55851Protein Accession#
Q9NZ42Gene Name
PSENEN
Gene Alias
MDS033, MSTP064, PEN-2, PEN2
Gene Description
presenilin enhancer 2 homolog (C. elegans)
Omim ID
607632Gene Ontology
HyperlinkGene Summary
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq
Other Designations
hematopoietic stem/progenitor cells protein MDS033|presenilin enhancer 2
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Interactome
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Pathway
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Disease
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