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Entrez GeneID

Protein Accession#

Gene Name

PIAS1

Gene Alias

DDXBP1, GBP, GU/RH-II, MGC141878, MGC141879, ZMIZ3

Gene Description

protein inhibitor of activated STAT, 1

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq

Other Designations

AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3

Entrez GeneID

Protein Accession#

Gene Name

PIAS2

Gene Alias

MGC102682, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz

Gene Description

protein inhibitor of activated STAT, 2

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq

Other Designations

Msx-interacting-zinc finger|protein inhibitor of activated STAT X|zinc finger, MIZ-type containing 4

Entrez GeneID

Protein Accession#

Gene Name

PIAS3

Gene Alias

FLJ14651, ZMIZ5

Gene Description

protein inhibitor of activated STAT, 3

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq

Other Designations

OTTHUMP00000015586|zinc finger, MIZ-type containing 5