KLKB1 recombinant monoclonal antibody, clone 9F6
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human KLKB1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human KLKB1.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of KLKB1 recombinant monoclonal antibody, clone 9F6 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KLKB1
Entrez GeneID
3818Protein Accession#
P03952Gene Name
KLKB1
Gene Alias
KLK3, PPK
Gene Description
kallikrein B, plasma (Fletcher factor) 1
Omim ID
229000Gene Ontology
HyperlinkGene Summary
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq
Other Designations
Kallikrein, plasma|kallikrein 3, plasma|kallikrein B plasma|kininogenin|plasma kallikrein B1
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