Products

Immunofluorescence

Immunofluorescent staining of human peripheral blood monocytes (PBM) with IL7R recombinant monoclonal antibody, clone YIL7R323 (Cat # RAB03616).
Immunofluorescence analysis of paraformaldehyde fixed human PBM cells on Shi-fix™ coverslips permeabilized with 0.15% Triton and stained with the chimeric r version of RAB03616 at 10 ug/mL for 1h followed by Alexa Fluor® 488 secondary antibody (1 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). The isotype control was stained with anti-Fluoresceinan antibody followed by Alexa Fluor® 488 secondary antibody.

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Entrez GeneID

3575

Gene Name

IL7R

Gene Alias

CD127, CDW127, IL-7R-alpha, IL7RA, ILRA

Gene Description

interleukin 7 receptor

Omim ID

146661 600802

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq

Other Designations

CD127 antigen|interleukin 7 receptor alpha chain